Protein K11-linked deubiquitination

Across TCGA patient cohorts, RNA activity of the Protein K11-linked deubiquitination pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TGM2, SMG7, and HSP90AA1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein K11-linked deubiquitination activity versus TGM2 in HNSC (Pearson r = -0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TGM2 →	-0.542	-0.075	.002	.001	3	6
LUAD	SMG7 →	+0.274	+0.071	<.001	<.001	3	5
COAD	HSP90AA1 →	+0.305	+0.035	.001	.003	3	5
LSCC	SPCS3 →	-0.326	-0.028	.001	.005	3	4
GBM	GTF3C3_S43 →	-0.400	-0.058	<.001	.001	3	4
GBM	APEX1 →	-0.362	-0.071	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035871 vs TGM2 — HNSC

Explore this scatter interactively →