Protein K11-linked deubiquitination

Across TCGA patient cohorts, RNA activity of the Protein K11-linked deubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VIRMA, RBIS, and UBR5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein K11-linked deubiquitination activity versus VIRMA in LUAD (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	VIRMA →	+0.347	+0.681	.002	.008	3	4
OV	RBIS →	+0.420	+0.395	.002	.008	2	4
BRCA	UBR5 →	+0.365	+0.172	.003	.004	3	3
BRCA	CABLES1 →	+0.607	+0.338	.003	<.001	3	3
BRCA	ABCA12 →	-1.029	-0.159	.001	.008	3	3
BRCA	DCAF16 →	+0.501	+0.221	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035871 vs VIRMA — LUAD

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