Protein K11-linked deubiquitination

Across TCGA cell cohorts, RNA activity of the Protein K11-linked deubiquitination pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SERPINA3, SPTB, and RMC1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SERPINA3 grouped by Protein K11-linked deubiquitination-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SERPINA3 →	+0.173	+1.528	.009	<.001	3	3
BREAST	SPTB →	-0.091	-0.573	<.001	<.001	3	3
CNS	RMC1 →	-0.231	-0.994	.002	<.001	3	3
CNS	RASGRP4 →	-0.217	-0.987	<.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	CDHR2 →	+0.230	+0.090	.001	.003	3	3
OESOPHAGUS	PF4 →	-0.148	-0.901	.006	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SERPINA3 by Protein K11-linked deubiquitination activity — LUNG_SCLC

Explore this box plot interactively →