Protein K11-linked deubiquitination

Across TCGA cell cohorts, RNA activity of the Protein K11-linked deubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OTUD4, FAM126B, and OXSR1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein K11-linked deubiquitination activity versus OTUD4 in LUNG_NSCLC_LUSC (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	OTUD4 →	+0.781	+1.056	<.001	.004	3	8
SOFT_TISSUE	FAM126B →	+0.457	+0.406	.001	.003	3	7
BREAST	OXSR1 →	+0.981	+0.645	<.001	.008	3	7
BREAST	SPATA5 →	+0.742	+0.616	<.001	.002	3	6
LUNG_NSCLC_LUAD	TNFAIP3 →	+1.654	+0.074	<.001	<.001	1	8
BLOOD_Lymphoma	FUBP1 →	+1.104	+0.059	<.001	<.001	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035871 vs OTUD4 — LUNG_NSCLC_LUSC

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