Response to potassium ion

Across TCGA patient cohorts, RNA activity of the Response to potassium ion pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GBP2, WIPI1, and EMD, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to potassium ion activity versus GBP2 in CCRCC (Pearson r = -0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	GBP2 →	-0.445	-0.062	<.001	<.001	3	5
HNSC	WIPI1 →	-0.397	-0.067	<.001	.004	3	4
LUAD	EMD →	+0.305	+0.072	.005	<.001	3	4
LUAD	KIF3A →	+0.222	+0.072	<.001	<.001	3	4
LSCC	CFL1_T25 →	+0.330	+0.061	.003	.008	3	4
BRCA	RNF214_S54 →	-0.490	-0.050	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035864 vs GBP2 — CCRCC

Explore this scatter interactively →