Response to potassium ion

Across TCGA cell cohorts, RNA activity of the Response to potassium ion pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OR2AG1, AVIL, and PDP1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OR2AG1 grouped by Response to potassium ion-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR2AG1 →	-0.030	-0.826	.001	.001	3	3
PANCREAS	AVIL →	+0.833	+0.825	.004	.009	3	3
CNS	PDP1 →	-1.080	-0.951	.002	.001	3	3
CNS	SYNPO →	-1.406	-0.897	.004	.001	3	3
UPPER_AERODIGESTIVE_TRACT	PECR →	+1.296	+0.347	<.001	.003	3	3
URINARY_TRACT	MAML3 →	+0.944	+0.336	.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OR2AG1 by Response to potassium ion activity — OVARY

Explore this box plot interactively →