Response to potassium ion

Across TCGA cell cohorts, RNA activity of the Response to potassium ion pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SYS1, ATP10D, and PTPN14, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to potassium ion activity versus SYS1 in BLOOD_Myeloma (Pearson r = -0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SYS1 →	-0.714	-1.264	.007	.004	3	6
OESOPHAGUS	ATP10D →	-1.222	-1.075	.007	.002	2	6
BLOOD_Lymphoma	PTPN14 →	-1.288	-1.011	.003	<.001	3	5
OESOPHAGUS	COL7A1 →	-2.585	-0.896	.001	.002	3	5
BLOOD_Lymphoma	ELL3 →	+4.355	+1.089	.003	.002	3	5
BLOOD_Lymphoma	LUZP1 →	-1.053	-0.770	.001	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035864 vs SYS1 — BLOOD_Myeloma

Explore this scatter interactively →