Glial cell-derived neurotrophic factor receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Glial cell-derived neurotrophic factor receptor signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CFAP74, PDGFRA, and WDR89, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CFAP74 grouped by Glial cell-derived neurotrophic factor receptor signaling pathway-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	CFAP74 →	+0.210	+0.512	.003	<.001	3	4
BLOOD_Leukemia	PDGFRA →	-0.245	-1.439	.008	.005	3	4
LUNG_SCLC	WDR89 →	-0.240	-2.225	.001	<.001	3	4
LUNG_SCLC	ANKRD45 →	+0.190	+1.795	.003	<.001	3	4
BONE	GPSM2 →	+0.357	+2.061	.001	<.001	3	4
BLOOD_Leukemia	KCNK16 →	-0.226	-1.341	.004	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CFAP74 by Glial cell-derived neurotrophic factor receptor signaling pathway activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →