Modulation of process of another organism

Across TCGA patient cohorts, RNA activity of the Modulation of process of another organism pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BEST1, MIR3945HG, and STX11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Modulation of process of another organism activity versus BEST1 in COAD (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	BEST1 →	+0.265	+0.186	<.001	.001	3	5
HNSC	MIR3945HG →	+0.781	+0.158	<.001	.001	3	5
PDAC	STX11 →	+0.334	+0.138	.006	.001	3	5
PDAC	CLEC4E →	+0.879	+0.199	.002	<.001	3	5
COAD	FCGR2C →	+0.779	+0.175	.001	.001	3	4
LSCC	TEC →	+0.390	+0.149	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035821 vs BEST1 — COAD

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