Modulation of process of another organism

Across TCGA cell cohorts, RNA activity of the Modulation of process of another organism pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TENM3, ZNF7, and NTAQ1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TENM3 grouped by Modulation of process of another organism-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TENM3 →	-1.529	-0.206	.005	.008	3	4
LIVER	ZNF7 →	+0.953	+0.389	<.001	<.001	3	4
LIVER	NTAQ1 →	+1.114	+0.323	.003	.009	3	4
OESOPHAGUS	ZNF594 →	-1.255	-0.176	<.001	.003	3	4
BONE	PRPS2 →	-1.018	-0.279	.005	.001	3	3
BONE	SMARCA4 →	+0.624	+0.216	.005	.008	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TENM3 by Modulation of process of another organism activity — CNS

Explore this box plot interactively →