Regulation of renal sodium excretion

Across TCGA patient cohorts, RNA activity of the Regulation of renal sodium excretion pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UCP2, SHQ1P1, and LFNG, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of renal sodium excretion activity versus UCP2 in LUAD (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	UCP2 →	-0.754	-1.232	.006	<.001	3	2
LUAD	SHQ1P1 →	+0.051	+1.157	.006	.002	3	2
BRCA	LFNG →	+1.142	+0.749	.001	<.001	2	3
BRCA	AGTR1 →	+2.608	+0.815	.001	.002	3	2
BRCA	CHODL →	-1.344	-1.004	.002	.001	3	2
BRCA	DALRD3 →	+0.731	+0.715	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035813 vs UCP2 — LUAD

Explore this scatter interactively →