Regulation of renal sodium excretion

Across TCGA cell cohorts, RNA activity of the Regulation of renal sodium excretion pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are XYLB, ATP6V1E1, and PALD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, XYLB grouped by Regulation of renal sodium excretion-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	XYLB →	+0.820	+1.632	.005	<.001	3	4
CNS	ATP6V1E1 →	-0.423	-0.870	.001	<.001	3	4
PANCREAS	PALD1 →	+1.202	+1.202	.009	<.001	2	5
PANCREAS	CIB2 →	+1.720	+1.504	<.001	<.001	3	4
URINARY_TRACT	USP27X →	-0.683	-1.703	<.001	<.001	3	4
LIVER	FAM214B →	-1.674	-1.646	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

XYLB by Regulation of renal sodium excretion activity — SOFT_TISSUE

Explore this box plot interactively →