Positive regulation of mitochondrial membrane permeability

Across TCGA patient cohorts, RNA activity of the Positive regulation of mitochondrial membrane permeability pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBXO16, UBE2S, and CFAP70, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mitochondrial membrane permeability activity versus FBXO16 in BRCA (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FBXO16 →	+0.464	+0.141	<.001	.003	3	5
GBM	UBE2S →	-0.543	-0.177	.003	.001	3	4
BRCA	CFAP70 →	+0.669	+0.171	.004	.001	3	4
GBM	FANK1 →	+0.598	+0.172	.001	.003	3	4
CCRCC	EPHX2 →	+0.723	+0.212	.005	<.001	3	4
LSCC	ANKRD42 →	+0.350	+0.213	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035794 vs FBXO16 — BRCA

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