Positive regulation of insulin secretion involved in cellular response to glucose stimulus

Across TCGA patient cohorts, RNA activity of the Positive regulation of insulin secretion involved in cellular response to glucose stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TK2, TPX2_S738, and IGF2BP2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of insulin secretion involved in cellular response to glucose stimulus activity versus TK2 in GBM (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TK2 →	+0.311	+0.045	<.001	<.001	3	6
BRCA	TPX2_S738 →	-0.716	-0.034	.009	.005	3	5
BRCA	IGF2BP2 →	-0.776	-0.045	<.001	<.001	3	5
LSCC	RIF1 →	-0.385	-0.039	.008	.002	3	5
LUAD	KPNA2 →	-0.400	-0.031	.001	.005	3	5
BRCA	ABT1 →	-0.348	-0.034	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035774 vs TK2 — GBM

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