Positive regulation of insulin secretion involved in cellular response to glucose stimulus

Across TCGA cell cohorts, RNA activity of the Positive regulation of insulin secretion involved in cellular response to glucose stimulus pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM161A, PNO1, and SLC47A1, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of insulin secretion involved in cellular response to glucose stimulus activity versus FAM161A in BLOOD_Myeloma (Pearson r = -0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	FAM161A →	-0.904	-0.106	.006	.009	2	11
BLOOD_Lymphoma	PNO1 →	-0.747	-0.070	<.001	<.001	3	8
LUNG_NSCLC_LUAD	SLC47A1 →	-1.108	-0.061	<.001	<.001	3	8
BONE	B4GALNT4 →	-2.070	-0.076	<.001	<.001	3	8
LUNG_NSCLC_LUAD	C1QL4 →	-0.779	-0.071	.009	.001	3	8
SOFT_TISSUE	ANKRD13B →	-1.161	-0.080	<.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035774 vs FAM161A — BLOOD_Myeloma

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