Insulin secretion involved in cellular response to glucose stimulus

Across TCGA patient cohorts, RNA activity of the Insulin secretion involved in cellular response to glucose stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL5, WDR13, and NCAPD2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Insulin secretion involved in cellular response to glucose stimulus activity versus RPL5 in BRCA (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RPL5 →	-0.221	-0.025	.002	.001	3	6
GBM	WDR13 →	+0.188	+0.035	<.001	<.001	3	6
BRCA	NCAPD2 →	-0.656	-0.032	<.001	<.001	3	6
PDAC	RFC1_T506 →	-0.775	-0.036	<.001	<.001	3	5
PDAC	RIF1_S782 →	-0.654	-0.033	.001	.001	3	5
BRCA	RRP1B_S513 →	-0.866	-0.026	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035773 vs RPL5 — BRCA

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