Insulin secretion involved in cellular response to glucose stimulus

Across TCGA patient cohorts, RNA activity of the Insulin secretion involved in cellular response to glucose stimulus pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF18A, ZNF407, and TESK2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Insulin secretion involved in cellular response to glucose stimulus activity versus KIF18A in HNSC (Pearson r = -0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	KIF18A →	-0.868	-0.515	<.001	<.001	3	5
CCRCC	ZNF407 →	-0.190	-0.289	.007	.004	3	4
CCRCC	TESK2 →	-0.283	-0.271	.001	.002	3	4
HNSC	ZWINT →	-0.889	-0.374	.003	.003	3	4
HNSC	CENPQ →	-0.801	-0.422	.003	.003	3	4
HNSC	MCM5 →	-0.646	-0.331	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035773 vs KIF18A — HNSC

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