Insulin secretion involved in cellular response to glucose stimulus

Across TCGA cell cohorts, RNA activity of the Insulin secretion involved in cellular response to glucose stimulus pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HNRNPF, SARM1, and KIFBP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Insulin secretion involved in cellular response to glucose stimulus activity versus HNRNPF in LARGE_INTESTINE (Pearson r = -0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HNRNPF →	-0.724	-0.283	<.001	.001	3	4
SKIN	SARM1 →	-1.462	-1.310	<.001	<.001	2	3
SOFT_TISSUE	KIFBP →	+1.143	+1.472	.008	<.001	3	2
SOFT_TISSUE	SNX13 →	+1.243	+1.527	.006	<.001	3	2
LUNG_SCLC	FAM78A →	-1.962	-1.720	.004	<.001	3	2
PANCREAS	ELL3 →	+0.856	+0.275	.008	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035773 vs HNRNPF — LARGE_INTESTINE

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