Interleukin-4-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Interleukin-4-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNX20, ARHGAP9, and ZMYND15, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Interleukin-4-mediated signaling pathway activity versus SNX20 in GBM (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SNX20 →	+0.606	+0.454	.004	.008	3	4
GBM	ARHGAP9 →	+0.600	+0.550	.001	.002	3	3
HNSC	ZMYND15 →	+0.439	+0.382	.008	.001	3	3
HNSC	SIGLEC10 →	+0.697	+0.480	.001	.002	2	4
HNSC	CD226 →	+0.633	+0.433	<.001	.005	3	3
HNSC	WAS →	+0.547	+0.391	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035771 vs SNX20 — GBM

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