Interleukin-4-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Interleukin-4-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL4R, TMBIM1, and JAK1, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Interleukin-4-mediated signaling pathway activity versus IL4R in BREAST (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	IL4R →	+1.642	+0.301	<.001	.005	3	14
LUNG_SCLC	TMBIM1 →	+1.884	+0.622	.003	.007	3	11
LUNG_SCLC	JAK1 →	+1.565	+1.171	<.001	<.001	3	11
OVARY	REEP2 →	-1.898	-0.251	<.001	<.001	3	10
OVARY	MVP →	+1.990	+0.252	<.001	<.001	3	10
LUNG_SCLC	IL13RA1 →	+1.983	+0.805	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035771 vs IL4R — BREAST

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