Interleukin-4-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Interleukin-4-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CASP1, NBPF20, and PI3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Interleukin-4-mediated signaling pathway activity versus CASP1 in LARGE_INTESTINE (Pearson r = -0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CASP1 →	-2.632	-0.427	.003	.003	3	4
LUNG_NSCLC_LUAD	NBPF20 →	+0.806	+0.352	.001	.004	3	3
LARGE_INTESTINE	PI3 →	-3.277	-0.425	.003	<.001	3	2
BLOOD_Leukemia	PAX9 →	+1.316	+0.696	<.001	.009	3	2
LUNG_NSCLC_LUAD	ACIN1 →	+0.858	+0.340	.003	.006	3	2
LUNG_NSCLC_LUAD	MED23 →	+0.847	+0.548	.006	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035771 vs CASP1 — LARGE_INTESTINE

Explore this scatter interactively →