Common myeloid progenitor cell proliferation

Across TCGA patient cohorts, RNA activity of the Common myeloid progenitor cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FBXO4_S12, CNBP_S121, and MTUS1_S1224, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Common myeloid progenitor cell proliferation activity versus FBXO4_S12 in HNSC (Pearson r = -0.01).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	FBXO4_S12 →	+0.501	+0.068	<.001	.002	3	6
CCRCC	CNBP_S121 →	-1.370	-0.060	<.001	.003	3	5
LUAD	MTUS1_S1224 →	+0.716	+0.052	.008	.004	3	5
OV	PMVK →	+0.435	+0.053	<.001	.001	3	5
BRCA	ARHGEF12_S1288 →	+0.632	+0.049	.001	.004	3	5
GBM	CABLES1_T415 →	+0.551	+0.064	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035726 vs FBXO4_S12 — HNSC

Explore this scatter interactively →