Common myeloid progenitor cell proliferation

Across TCGA patient cohorts, RNA activity of the Common myeloid progenitor cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITPKB, ITPKB-AS1, and MRPL49, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Common myeloid progenitor cell proliferation activity versus ITPKB in GBM (Pearson r = -0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ITPKB →	+0.856	+0.752	<.001	<.001	3	4
HNSC	ITPKB-AS1 →	+0.915	+0.931	<.001	<.001	3	4
CCRCC	MRPL49 →	-0.197	-0.214	.001	.007	3	4
COAD	NDUFS8 →	-0.294	-0.233	.006	.005	3	3
LSCC	RNF121 →	-0.465	-1.039	<.001	<.001	3	3
LSCC	SCYL1 →	-0.272	-0.842	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035726 vs ITPKB — GBM

Explore this scatter interactively →