Common myeloid progenitor cell proliferation

Across TCGA cell cohorts, RNA activity of the Common myeloid progenitor cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCAF11, ITPRIPL2, and TULP3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SCAF11 grouped by Common myeloid progenitor cell proliferation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SCAF11 →	+0.642	+1.127	.007	.006	3	3
BLOOD_Leukemia	ITPRIPL2 →	+1.393	+1.464	.001	<.001	3	3
PANCREAS	TULP3 →	+0.865	+0.848	.001	.002	3	3
LIVER	PLSCR3 →	+1.669	+1.377	<.001	.002	3	3
LUNG_SCLC	HOXA4 →	+2.340	+1.196	.003	.005	3	3
LUNG_NSCLC_LUAD	VAC14 →	-0.684	-0.621	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SCAF11 by Common myeloid progenitor cell proliferation activity — BLOOD_Leukemia

Explore this box plot interactively →