Interleukin-12-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Interleukin-12-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMOD2, KIF1A, and AMIGO1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Interleukin-12-mediated signaling pathway activity versus TMOD2 in GBM (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TMOD2 →	+0.444	+0.263	.002	.005	3	4
GBM	KIF1A →	+0.779	+0.312	<.001	<.001	3	4
CCRCC	AMIGO1 →	+0.909	+0.891	<.001	<.001	3	3
HNSC	CORO1CP1 →	+0.381	+0.217	.008	.003	3	3
BRCA	NRM →	-0.585	-0.614	.005	.001	3	3
PDAC	SEC23A →	-0.306	-0.700	.008	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035722 vs TMOD2 — GBM

Explore this scatter interactively →