Intraciliary retrograde transport

Across TCGA cell cohorts, RNA activity of the Intraciliary retrograde transport pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCAM, RNASEL, and PPA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MCAM grouped by Intraciliary retrograde transport-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MCAM →	+3.680	+0.402	<.001	<.001	3	5
STOMACH	RNASEL →	-1.258	-0.298	<.001	.004	3	4
LIVER	PPA1 →	-0.736	-1.586	.001	.005	3	4
SOFT_TISSUE	PDLIM3 →	+3.391	+1.057	.003	.007	3	4
SOFT_TISSUE	POLR3C →	+0.748	+1.003	.006	.007	3	4
LUNG_SCLC	FOXRED2 →	+0.996	+0.261	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MCAM by Intraciliary retrograde transport activity — STOMACH

Explore this box plot interactively →