Intraciliary retrograde transport

Across TCGA pan-cancer cohorts, RNA activity of the Intraciliary retrograde transport pathway is associated with patient survival in 18 of 34 cancer lineages. Pathway activity is summarized from the expression of its 13 member genes.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher Intraciliary retrograde transport pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BRCA and READ, show the opposite pattern, with higher activity associated with better survival.

BRCA, ACC, and READ are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Tertile	III,IV	0.926	0.772	<.001	49	view →
ACC	DFS	Quartile	All	0.187	0.634	<.001	49	view →
READ	OS	Median	II,III,IV	0.773	0.503	.006	44	view →
LGG	DFS	Tertile	All	0.265	0.488	<.001	32	view →
KIRC	DFS	Median	All	0.864	0.729	.003	26	view →
LIHC	DFS	Quartile	All	0.398	0.627	.001	24	view →
THCA	OS	Tertile	II,III,IV	0.611	0.875	.002	21	view →
SKCM	OS	Quartile	II,III,IV	0.450	0.295	.009	17	view →
LAML	DFS	Median	All	0.655	0.493	.022	8	view →
KICH	DFS	Tertile	III,IV	0.373	1.000	.013	8	view →
SARC	OS	Tertile	All	0.399	0.848	<.001	8	view →
HNSC	OS	Tertile	IV	0.585	0.415	.024	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

GO:0035721–BRCA (DFS)

Open the BRCA breakdown →