Mitochondrial protein catabolic process

Across TCGA cell cohorts, RNA activity of the Mitochondrial protein catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SENP3-EIF4A1, GMNN, and AGXT2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SENP3-EIF4A1 grouped by Mitochondrial protein catabolic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SENP3-EIF4A1 →	-0.158	-0.111	.008	<.001	3	6
OESOPHAGUS	GMNN →	-0.243	-0.082	.001	.006	2	6
LIVER	AGXT2 →	+0.166	+0.180	<.001	.003	3	5
STOMACH	BTN3A3 →	+0.164	+0.261	.003	.004	3	5
OVARY	PRSS23 →	-0.270	-0.146	<.001	<.001	3	5
CNS	SSRP1 →	-0.257	-0.091	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SENP3-EIF4A1 by Mitochondrial protein catabolic process activity — LARGE_INTESTINE

Explore this box plot interactively →