TRIF-dependent toll-like receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the TRIF-dependent toll-like receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBC, PHYKPL, and CASP4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UBC grouped by TRIF-dependent toll-like receptor signaling pathway-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	UBC →	-0.843	-1.182	.009	.003	3	4
SKIN	PHYKPL →	-0.727	-1.082	.003	.002	3	4
SKIN	CASP4 →	-0.703	-0.728	.004	.009	3	4
KIDNEY	CETN2 →	+0.625	+1.184	.002	.006	3	4
OVARY	ADAM11 →	+0.859	+1.038	.009	<.001	3	4
BONE	NKIRAS2 →	+1.028	+1.284	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UBC by TRIF-dependent toll-like receptor signaling pathway activity — STOMACH

Explore this box plot interactively →