TRIF-dependent toll-like receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the TRIF-dependent toll-like receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRAF3, EIF2AK4, and TRAF6, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, TRIF-dependent toll-like receptor signaling pathway activity versus TRAF3 in BONE (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	TRAF3 →	+1.033	+0.113	<.001	<.001	3	11
KIDNEY	EIF2AK4 →	+0.713	+0.097	.001	<.001	3	9
STOMACH	TRAF6 →	+0.877	+0.122	.001	.001	3	8
LIVER	KLF16 →	+0.730	+0.103	.005	.002	3	7
BLOOD_Leukemia	IKBKB →	+0.519	+0.052	.003	<.001	3	6
BLOOD_Lymphoma	ARID3A →	+1.393	+0.063	<.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035666 vs TRAF3 — BONE

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