TRIF-dependent toll-like receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the TRIF-dependent toll-like receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPTLC3, ECD, and ASCC1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, TRIF-dependent toll-like receptor signaling pathway activity versus SPTLC3 in SOFT_TISSUE (Pearson r = -0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SPTLC3 →	-3.027	-0.241	.001	.001	3	3
SKIN	ECD →	+0.472	+0.301	.003	.004	3	3
SKIN	ASCC1 →	+0.468	+0.352	.001	.001	3	3
SOFT_TISSUE	PTPRK →	-2.312	-0.241	<.001	.001	3	2
SOFT_TISSUE	IL15 →	-2.095	-0.241	.003	.001	3	2
SOFT_TISSUE	PTPRM →	-4.177	-0.241	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035666 vs SPTLC3 — SOFT_TISSUE

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