Interleukin-18-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Interleukin-18-mediated signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ACTR2, IL18, and ANXA2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Interleukin-18-mediated signaling pathway activity versus ACTR2 in BRCA (Pearson r = 0.13).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ACTR2 →	+0.216	+0.037	.002	.009	3	7
OV	IL18 →	+0.623	+0.061	<.001	.001	3	7
UCEC	ANXA2 →	+0.479	+0.075	<.001	.002	3	7
LSCC	RASA3 →	+0.247	+0.073	<.001	<.001	3	7
BRCA	ARPC2 →	+0.304	+0.053	<.001	<.001	3	7
GBM	ARPC1B →	+0.467	+0.114	.003	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035655 vs ACTR2 — BRCA

Explore this scatter interactively →