Interleukin-18-mediated signaling pathway

Across TCGA pan-cancer cohorts, RNA activity of the Interleukin-18-mediated signaling pathway pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 9 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher Interleukin-18-mediated signaling pathway pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UVM and CESC, show the opposite pattern, with higher activity associated with better survival.

HNSC, LGG, and UVM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	III,IV	0.678	0.847	<.001	58	view →
LGG	DFS	Median	All	0.258	0.501	<.001	48	view →
UVM	OS	Tertile	II,III,IV	0.734	0.451	.008	46	view →
LUAD	DFS	Median	All	0.611	0.740	.020	18	view →
BRCA	OS	Tertile	III,IV	0.770	0.907	.005	16	view →
SCLC	OS	Quartile	All	0.335	0.694	.004	15	view →
ESCA	OS	Tertile	IV	0.219	0.916	.024	12	view →
CESC	DFS	Quartile	IV	0.652	0.166	.030	12	view →
THYM	DFS	Tertile	All	0.786	1.000	.010	11	view →
ACC	OS	Median	All	0.833	0.509	.017	11	view →
LIHC	OS	Quartile	All	0.839	0.626	.019	8	view →
OV	DFS	Tertile	IV	0.208	0.411	.049	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0035655–HNSC (OS)

Open the HNSC breakdown →