Interleukin-18-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Interleukin-18-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEACAM21, CD86, and SNHG19, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Interleukin-18-mediated signaling pathway activity versus CEACAM21 in LSCC (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CEACAM21 →	+0.450	+0.245	.001	.001	3	5
LSCC	CD86 →	+0.617	+0.333	.001	<.001	3	4
LSCC	SNHG19 →	-0.622	-0.283	.001	.003	3	4
LSCC	HDHD5-AS1 →	-0.654	-0.332	<.001	<.001	3	4
LSCC	LINC02285 →	+0.126	+0.155	.003	.006	3	4
COAD	FAM183A →	-0.565	-0.591	.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035655 vs CEACAM21 — LSCC

Explore this scatter interactively →