Interleukin-18-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Interleukin-18-mediated signaling pathway pathway is significantly associated with the drug response of multiple features, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are CCT245467, Linsitinib, and Nilotinib, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCT245467 grouped by Interleukin-18-mediated signaling pathway-low versus -high activity in PANCREAS.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CCT245467 →	+0.490	+0.256	.035	.015	3	3
PANCREAS	Linsitinib →	-0.339	-0.247	.002	.025	3	3
BLOOD_Lymphoma	Nilotinib →	-0.673	-0.137	.049	.046	3	2
KIDNEY	CP466722 →	+0.524	+0.414	.034	.036	3	1
PANCREAS	XAV939 →	-0.673	-0.256	.012	.015	3	1
PANCREAS	FR-180204 →	+0.634	+0.335	.036	.021	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCT245467 by Interleukin-18-mediated signaling pathway activity — PANCREAS

Explore this box plot interactively →