Exploration behavior

Across TCGA patient cohorts, RNA activity of the Exploration behavior pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PELATON, CSF3R, and KNDC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Exploration behavior activity versus PELATON in HNSC (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PELATON →	+0.499	+0.614	.005	<.001	3	5
LSCC	CSF3R →	+0.982	+0.795	.001	.001	3	4
GBM	KNDC1 →	+0.829	+0.391	<.001	<.001	3	4
LSCC	LRRK2 →	+1.623	+1.081	<.001	<.001	3	4
BRCA	KCNE1 →	+0.226	+0.502	.003	.004	3	4
GBM	PNMA5 →	+0.627	+0.583	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035640 vs PELATON — HNSC

Explore this scatter interactively →