Maintenance of blood-brain barrier

Across TCGA cell cohorts, RNA activity of the Maintenance of blood-brain barrier pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACTG1, ACTB, and OSTCP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ACTG1 grouped by Maintenance of blood-brain barrier-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ACTG1 →	-0.319	-0.641	<.001	.004	3	8
LUNG_NSCLC_LUAD	ACTB →	-0.343	-0.628	<.001	.003	3	8
BREAST	OSTCP1 →	+0.170	+0.494	<.001	.005	3	3
STOMACH	SALL1 →	-0.171	-1.192	<.001	.004	3	3
CNS	TAPBPL →	-0.208	-1.185	<.001	<.001	3	3
CNS	PLRG1 →	-0.306	-1.025	.006	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ACTG1 by Maintenance of blood-brain barrier activity — BREAST

Explore this box plot interactively →