Maintenance of blood-brain barrier

Across TCGA pan-cancer cohorts, RNA activity of the Maintenance of blood-brain barrier pathway is associated with patient survival in 19 of 34 cancer lineages. Pathway activity is summarized from the expression of its 38 member genes.

The strongest signal is observed in brain lower grade glioma (LGG), where higher Maintenance of blood-brain barrier pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRC and UCS, show the opposite pattern, with higher activity associated with better survival.

LGG, KIRP, and STAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.738	0.868	<.001	49	view →
KIRP	OS	Quartile	III,IV	0.093	0.809	.002	48	view →
STAD	DFS	Quartile	All	0.319	0.535	.001	45	view →
THCA	OS	Tertile	II,III,IV	0.957	1.000	.001	42	view →
CESC	DFS	Tertile	All	0.780	0.883	.002	34	view →
KIRC	DFS	Tertile	IV	0.517	0.183	.008	31	view →
ESCA	DFS	Quartile	All	0.121	0.828	.004	27	view →
UCS	DFS	Tertile	IV	0.821	0.239	.024	24	view →
MESO	OS	Median	II,III,IV	0.305	0.486	.012	18	view →
LUSC	OS	Quartile	All	0.262	0.481	.002	14	view →
UVM	DFS	Quartile	III,IV	0.432	1.000	.022	12	view →
READ	DFS	Median	III,IV	0.483	0.206	.046	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

GO:0035633–LGG (OS)

Open the LGG breakdown →