Maintenance of blood-brain barrier

Across TCGA cell cohorts, RNA activity of the Maintenance of blood-brain barrier pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NFE2L1, GSTM4, and S100A5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NFE2L1 grouped by Maintenance of blood-brain barrier-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	NFE2L1 →	+0.162	+0.225	.006	.004	2	6
BREAST	GSTM4 →	+0.132	+0.258	.007	<.001	3	4
LUNG_NSCLC_LUSC	S100A5 →	+0.254	+0.295	.001	.004	3	4
LUNG_NSCLC_LUAD	TPRKB →	+0.175	+0.292	<.001	.005	3	4
LARGE_INTESTINE	GGPS1 →	-0.274	-0.300	.001	.007	3	4
URINARY_TRACT	TERF1 →	+0.130	+0.358	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NFE2L1 by Maintenance of blood-brain barrier activity — KIDNEY

Explore this box plot interactively →