Maintenance of blood-brain barrier

Across TCGA cell cohorts, RNA activity of the Maintenance of blood-brain barrier pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FOXC1, NEDD9, and SLC26A10, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of blood-brain barrier activity versus FOXC1 in BREAST (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	FOXC1 →	+2.139	+0.220	<.001	.003	3	7
BONE	NEDD9 →	+3.740	+0.618	<.001	.001	3	6
OESOPHAGUS	SLC26A10 →	-1.601	-0.254	.002	.001	3	5
OESOPHAGUS	TMPRSS4 →	+3.555	+0.280	<.001	.002	3	5
OVARY	HSPG2 →	+1.696	+0.264	.002	.002	3	5
OESOPHAGUS	NLGN2 →	-2.070	-0.224	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035633 vs FOXC1 — BREAST

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