Ceramide transport

Across TCGA patient cohorts, RNA activity of the Ceramide transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STAG1, TERF1, and IGF2BP3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ceramide transport activity versus STAG1 in GBM (Pearson r = -0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	STAG1 →	-0.278	-0.049	.002	.004	3	5
LSCC	TERF1 →	-0.308	-0.045	<.001	.003	3	5
CCRCC	IGF2BP3 →	+1.629	+0.052	.001	.005	3	5
BRCA	PRODH →	+0.772	+0.041	.003	.005	3	5
LSCC	YWHAG →	+0.209	+0.050	.001	<.001	3	4
GBM	BRPF1_S460 →	-0.328	-0.054	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035627 vs STAG1 — GBM

Explore this scatter interactively →