Ceramide transport

Across TCGA cell cohorts, RNA activity of the Ceramide transport pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CERT1, ABCA13, and ABCA12, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CERT1 grouped by Ceramide transport-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CERT1 →	-0.238	-1.286	<.001	<.001	3	8
BLOOD_Leukemia	ABCA13 →	-0.219	-0.902	.001	.002	3	7
LUNG_NSCLC_LUAD	ABCA12 →	-0.110	-0.600	.007	.007	3	6
BLOOD_Lymphoma	MMS22L →	+0.621	+1.085	<.001	.007	3	4
OESOPHAGUS	RBM41 →	-0.111	-0.973	.005	.005	3	4
BLOOD_Leukemia	IHH →	+0.230	+1.279	.006	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CERT1 by Ceramide transport activity — BREAST

Explore this box plot interactively →