Ceramide transport

Across TCGA cell cohorts, RNA activity of the Ceramide transport pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RHBDL1, GNG13, and IGFBP3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RHBDL1 grouped by Ceramide transport-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	RHBDL1 →	-1.666	-2.045	.002	<.001	3	5
STOMACH	GNG13 →	-0.417	-0.882	.006	.003	3	4
SKIN	IGFBP3 →	-2.762	-1.196	.001	<.001	3	4
SKIN	PALM3 →	-0.620	-0.911	.004	.003	3	4
BLOOD_Leukemia	HSBP1L1 →	-1.169	-1.033	.003	<.001	3	4
PANCREAS	BCDIN3D →	-0.480	-1.032	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RHBDL1 by Ceramide transport activity — URINARY_TRACT

Explore this box plot interactively →