Ceramide transport

Across TCGA cell cohorts, RNA activity of the Ceramide transport pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PNLDC1, OR7E91P, and EML3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PNLDC1 grouped by Ceramide transport-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PNLDC1 →	-0.238	-0.165	<.001	<.001	3	4
LUNG_SCLC	OR7E91P →	+0.146	+0.120	.008	.007	3	4
BLOOD_Leukemia	EML3 →	-0.296	-0.125	.002	.007	3	4
CNS	STK40 →	-0.170	-0.092	.004	<.001	3	4
PANCREAS	H2AC4 →	-0.194	-0.102	.004	.001	3	4
PANCREAS	COL4A4 →	+0.200	+0.112	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PNLDC1 by Ceramide transport activity — LUNG_SCLC

Explore this box plot interactively →