Ceramide transport

Across TCGA cell cohorts, RNA activity of the Ceramide transport pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VAPA, ABCC1, and RAB12, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ceramide transport activity versus VAPA in BONE (Pearson r = 0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	VAPA →	+1.765	+0.298	.001	.004	3	6
LUNG_NSCLC_LUSC	ABCC1 →	-1.018	-0.170	.004	<.001	3	5
LIVER	RAB12 →	+1.134	+0.246	.003	.003	3	5
SKIN	UBR1 →	-0.722	-0.196	.003	.007	3	4
BLOOD_Lymphoma	WDR20 →	-0.417	-0.102	.002	.001	3	4
BLOOD_Lymphoma	FAM126B →	-0.724	-0.126	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035627 vs VAPA — BONE

Explore this scatter interactively →