ER to Golgi ceramide transport

Across TCGA patient cohorts, RNA activity of the ER to Golgi ceramide transport pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are H1-10, PLOD3, and DOCK11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ER to Golgi ceramide transport activity versus H1-10 in OV (Pearson r = -0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	H1-10 →	-0.460	-0.053	.005	<.001	3	5
BRCA	PLOD3 →	+0.470	+0.048	<.001	<.001	3	5
CCRCC	DOCK11 →	+0.341	+0.048	<.001	.002	3	5
CCRCC	CBX7 →	-0.381	-0.056	.003	.002	3	4
CCRCC	FGFR1OP2 →	-0.186	-0.042	.001	.007	3	4
LUAD	ING5_S148 →	-0.244	-0.038	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035621 vs H1-10 — OV

Explore this scatter interactively →