ER to Golgi ceramide transport

Across TCGA patient cohorts, RNA activity of the ER to Golgi ceramide transport pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAPK6P6, ZNF836, and MRFAP1L1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ER to Golgi ceramide transport activity versus MAPK6P6 in LUAD (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MAPK6P6 →	-0.030	-0.090	.002	.008	3	3
PDAC	ZNF836 →	-0.341	-0.215	.003	.001	3	3
LSCC	MRFAP1L1 →	-0.389	-0.209	.001	<.001	3	3
PDAC	ZNF766 →	-0.264	-0.198	.005	.001	3	3
PDAC	RBBP6 →	-0.185	-0.180	.002	.006	3	3
OV	NUDCD2 →	-0.467	-0.163	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035621 vs MAPK6P6 — LUAD

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