ER to Golgi ceramide transport

Across TCGA cell cohorts, RNA activity of the ER to Golgi ceramide transport pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GLTP, CERT1, and OR51D1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GLTP grouped by ER to Golgi ceramide transport-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	GLTP →	-0.252	-1.381	<.001	<.001	3	5
BREAST	CERT1 →	-0.200	-1.163	<.001	<.001	3	4
LUNG_NSCLC_LUAD	OR51D1 →	+0.144	+1.024	.006	.006	2	5
LUNG_NSCLC_LUAD	ADH1C →	+0.180	+0.893	.003	.006	3	4
LUNG_NSCLC_LUAD	CCL15-CCL14 →	+0.086	+1.140	.004	<.001	2	5
SOFT_TISSUE	COQ8B →	+0.535	+1.645	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GLTP by ER to Golgi ceramide transport activity — BREAST

Explore this box plot interactively →