ER to Golgi ceramide transport

Across TCGA cell cohorts, RNA activity of the ER to Golgi ceramide transport pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDNF, ADAD1, and CDC23, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDNF grouped by ER to Golgi ceramide transport-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CDNF →	+0.298	+0.085	.007	.005	3	4
BLOOD_Lymphoma	ADAD1 →	+0.344	+0.167	.002	.002	3	4
LIVER	CDC23 →	+0.589	+0.140	.001	<.001	3	4
KIDNEY	PEX13 →	-0.234	-0.070	.005	<.001	3	4
LIVER	GSR →	+0.236	+0.092	.001	.001	3	4
LUNG_NSCLC_LUSC	H2BC5 →	+0.210	+0.090	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDNF by ER to Golgi ceramide transport activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →