Stress granule disassembly

Across TCGA patient cohorts, RNA activity of the Stress granule disassembly pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIR1972-1, KMT2A, and FAM193A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Stress granule disassembly activity versus MIR1972-1 in COAD (Pearson r = -0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIR1972-1 →	-0.796	-0.113	<.001	.004	3	4
COAD	KMT2A →	-0.502	-0.153	.009	<.001	3	4
OV	FAM193A →	-0.845	-0.107	.007	.004	3	3
OV	ILDR1 →	-0.603	-0.147	.002	<.001	3	3
OV	TUT1 →	-0.395	-0.125	.003	.001	3	3
OV	MOV10 →	-0.622	-0.177	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035617 vs MIR1972-1 — COAD

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